마우스에서 히알우론산 나트륨이 항염효과에 미치는 영향에 관한 연구
The effect of hyaluronic acid on anti-inflammatory action in mouse
김상균, 이형석, 변광섭, 이영주, 홍순민, 최미라, 박준우,
소속 상세정보
김상균 ( Kim Sang-Hyun ) - 한림대학교 의과대학 구강악안면외과학교실
이형석 ( Lee Hyung-Seok ) - 한림대학교 의과대학 내과학교실
변광섭 ( Byeon kwang-Seob ) - 한림대학교 강동성심병원 구강악안면외과
이영주 ( Lee Young-Joo ) - 한림대학교 강동성심병원 구강악안면외과
홍순민 ( Hong Soon-Min ) - 한림대학교 강동성심병원 구강악안면외과
최미라 ( Choi Mee-Ra ) - 한림대학교 의과대학 치과보철학교실
박준우 ( Park Jun-Woo ) - 한림대학교 강동성심병원 구강악안면외과
KMID : 0355620100360010016
Abstract
Purpose:The purpose of this study was not only to evaluate the relative mRNA expression of interleukin-1β(IL-1β), cyclooxygenase2 (COX-2) and prostaglandin E2 (PGE2) by RT-PCR analysis but to observe pattern of edema by light microscopic and electron microscope after topical apply of hyaluronic acid in inflammation-guided mouse.
Material and methods:Mice of this study were devided into 4 groups: Control group (no inflammation guided), Positive control (inflammation guided + vaselin apply), Protopic group (inflammation guided + protopic apply), Hyaluronic group (inflammation guided + hyaluronic acid apply).
Results:Hyaluronic group showed less expressions of IL-1β, COX-2, PGE2 than those of positive control & protopic group. Hyaluronic group revealed a decreased inflammation than positive control & protopic group in Light Microscope. Hyaluronic group appeared decreased edema of ear compare to positive control & protopic group in Elecron Microscope.
Conclusion:It was considered that hyaluronic acid has an antiinflammatory effect for intercepting the gene expression of cytokines related to inflammation.
키워드
Hyaluronic acid;Anti-inflammatory agent;Mice
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